- Expression of Alpha Fetoprotein, Transforming Growth Factor, Epidermal Growth Factor and Alpha-1-Antitrypsin in Gastric Cancer.
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Sook Guem Jeong, Hwan Jun Choi, Ja Young Koo, Man Ha Huh
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Korean J Pathol. 1994;28(5):485-492.
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- The immunohistochemical expression of transforming growth factor-beta(TGF-beta), epidermal growth factor(EGF) and alpha-1-antitrypsin(AAT) was studied in 47cases of endoscopic biopsy matearials of gastric carcinoma to determine me correlation to the expression of alpha fetoprotein(AFP). And immunoreactivity of the antigens was correlated to me degree of tumor infiltrating lymphocytes and histologic differentiation of the tumors. And the results were analyzed to elucidate pathological AFP-producing gastric cancer. The results were summarized as follows. AFP immunoreactivity was demonstrated in 30 cases(63.8%) of the tumors, TGF-beta in 26 cases(55.3%), EGF in l4 cases(29.8%) and AAT in l0 cases(21.3%). The incidence of expression of the antigens was significantly higher in the cases of elevated serum AFP(>2ng/ml) than that of the cases with normal serum AFP(p<0.05). There was no relation between the expression of antigens and histological differentiation of gastric cancer. The expression of AFP and TGF-beta revealed good correlation(k=0.72). The relation between expression of TGF-beta and AAT and the degree of tumor infiltrating lymphocytes disclosed negative correlation(p<0.05). These results suggest that TGF-beta and AAT prodution contribute to the worse prognosis of AFP-producting gastric cancer. Possible immunosuppressive action of TGF-beta and AAT in the cancer tissue is discussed.
- Pineoblastoma with Neuronal Differentiation: A case report.
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Sook Guem Jeong, Hee Kyung Chang, Man Ha Huh
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Korean J Pathol. 1994;28(4):433-435.
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- A case of pineoblastoma in a 28-year-old male is reported. A computerized tomography showed hydrocephalus and a mass in the pineal region. Histologically, the tumor is composed of regular, patternless aggregates of small round undifferentiated cells, resembling medulloblastoma-retinoblastoma group. Immunohistochemical reactivity of the neoplastic cells for neuron specific enolase and synaptophysin demonstrates neuronal differentiation. The patient underwent partial resection of the mass followed by radiotherapy. The patient had no cerebrospinal dissemination at 8 month follow-up. The pineoblastoma is a highly malignant neoplasm, one of the class of primitive neuroectodermnal tumors. The tumor is a very rare pineal parenchymal meoplasms, representing an incidence of less than 0.1% of intracranial tumors. This is the first case of pineoblastoma reported in Korea. In this report the divergent differentiation of the tumor is discussed, along with review of literatures.
- Cystic Lymphangioma of the Stomach: A case report.
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Soon Ae Ok, Sook Guem Jeong, Bang Hur, Man Ha Huh
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Korean J Pathol. 1993;27(6):670-672.
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- Cystic lymphangiomas of the stomach are extremely rare.
These usually present as asymptomatic, polypoid lesion consisting of cystically dilated lymphatic vessels, which are submucosal in location. We report a case of cystic lymphangioma of the stomach. The patient is a 55 year-old woman who has complained of dull pain on epigastrium for 10 years. The mass measures 6x5 cm in cross diameter and is mainly located in the subserosal layer along lesser curvature. Microscopically, the tumor reveals a large number of dilated lymphatic cysts containing serous fluid, lined by a layer of flattened endothelial cells. Ultrastructurally, lining endothelial cells show thin discontinuous basal lamina, in contrast to normal lymphatics.
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